Ron Hites graduated from Oakland University in 1964 and from the Massachusetts Institute of Technology (MIT) in 1968. He joined the faculty of MIT as an assistant professor of chemical engineering in 1972, and he moved to Indiana University in 1979. He was promoted to the rank of Distinguished Professor in 1989. He retired in 2020 and is a Distinguished Professor Emeritus.
Hites pioneered a new method of measuring trace levels of potentially toxic persistent organic pollutants in the environment using gas chromatographic mass spectrometry. His research focused on the sources, fates, and effects of trace levels of potentially toxic persistent organic pollutants in the environment. He authored hundreds of papers and several books. He has trained dozens of doctoral students and post-doctoral associates. He was an associate editor of Environmental Science & Technology from 1990-2019. He is a Charter Fellow of the American Chemical Society, a Charter Fellow of the Society for Environmental Toxicology and Chemistry, and a Fellow of the American Association for the Advancement of Science.